A bioreactor for high performing microbial production
The GEA Axenic® M product line is an industrial-scale bioreactor system that has been designed specifically for cultivation and precision fermentation in the food industry.
Based on a stirred tank reactor approach, the Axenic® M Bioreactor has been developed to let you unlock the benefits of fed-batch and continuous cultivation, allowing you to grow engineered cells at commercial scale.
Importantly, our Axenic® portfolio of bioreactor technology isn’t just an adaptation of units designed for pharma or traditional biotech applications. We’ve focused on developing fully regulatory compliant solutions that will let you unlock a multitude of opportunities in the exciting sector of “new foods,” including mycelium and alternative proteins.
To do this we’ve had a rethink on the design of bioreactors. Rather than expect you to adapt cells to a fixed bioreactor design, we’ve focused on cell requirements, such as oxygen transfer, temperature, and factors such as their shear sensitivity, to really understand what is needed to optimize bioreactor design and function. We’ve done this using our Virtual Bioreactor Testing technology.
GEA Virtual Bioreactor Testing is an advanced digital twin simulation tool that allows us to unpick a bioreactor design and understand what is happening within the system, and how cells will likely be affected. Using our technology we can derive important data on shear forces, optimum temperature, oxygen transfer rates, and other key criteria. With this knowledge we’ll work with you to fine tune the physical setup of your bioreactor as well as key parameters such as the delivery of oxygen and nutrients to your microbial cells, to maximize yield and efficiency. Ultimately, the results from detailed testing and validation can help you to generate proof of concept, demonstrate scale up - from lab scale, to pilot and then industrial volumes - as well as evaluate new cell strains. This depth of insight can be invaluable in helping you to innovate and generate new product types.
Whether we're discussing gas fermentation, precision fermentation, or mycelium production, some typically common factors that need to be considered include the high demand for gas transfer rates and the ability to precisely control gradients. This is why the Axenic® M design makes it possible to maintain accurate control in a half-full configuration during the initial stage of a fed-batch process, as well as when the bioreactor is completely filled. For applications with high cell growth rates our external cooling loops make it possible to utilize all capacity without needing to reduce production speed to keep the process at the optimal temperature. Importantly, and compared with traditional cooling coils, our external cooling loops help to reduce temperature variations and gradients, so you can better maintain the correct temperature throughout the tank. External cooling loops also reduce the risk of incomplete tank cleaning.
For accurate bioreactor control it's important to understand that the readings for some measurements, such as dissolved oxygen concentrations, will depend on where in the tank the measurement is made. We understand that it's important to consider probe placement, as well as provide the option for control based on gas transfer rates rather than on dissolved gas concentrations. We also offer an optional advanced sensor package that lets you measure metabolic heat generation, which can help to further optimize large scale processes.
Importantly, the Axenic® M is fully automated, with valve feedback alerting operators to any valve or system failure, and sterile barriers to media and harvest lines supporting efficient production 24/7. Our GEA Codex® process control platform helps to ensure process stability and safety during day-to-day operation, allows for precise recipe control, and reduces manual tasks, so there’s less risk of human error or contamination. The combination of automation and monitoring also helps to reduce waste and the use of resources and media. Install GEA Codex® and you can expect higher process repeatability and reliability, and reduced downtime.
Test facilities for new food applications
Partner with GEA on your new food journey, and you won’t just get state-of-the-art bioreactor equipment. We like to start with a basic design study that details what you do today, and so together we can evaluate your processes and make sure that your new facility will be a good fit with equipment upstream and downstream of the bioreactors.
At our New Food Application and Technology Center of Excellence (ATC) you can evaluate our equipment, work with GEA experts to carry out physical and computational testing, and access all of our process, engineering and cell culture/fermentation knowhow spanning multiple industries, from dairy, to brewery and pharma.
So, wherever you are on your journey, let us work with you to evaluate your needs and design a GEA bioreactor system that will match the needs of your cell-based production process.
Axenic is registered as a trademark in several countries worldwide.
GEA 将最新的计算流体动力学工具和动力学模型与先进的计算能力相结合,产生了一种可以数字化反映从实验室工作台到工业规模的几乎任何生物反应器环境的技术。
新食品应用和技术卓越中心 (ATC) 已成为支持新兴细胞农业领域创新的中心枢纽。该 GEA 设施提供领先的生物反应器和精密发酵,并在高度灵活的中试规模设置中分配上游和下游技术,因此您可以试验和评估发酵和细胞培养过程,并扩大规模。
The GEA Axenic C product line is an industrial-scale bioreactor system that has been designed specifically for cultivating mammalian and other eukaryotic cells in the food industry.
GEA Axenic® P is a flexible pilot-scale bioreactor designed to help you scale up cell cultivation and precision fermentation processes for a wide range of new food application.
优质冷链管理的重要性不可低估。确保易腐食品在食用时安全且高质量是冷链设施运营商的巨大责任。GEA 处于为冷库和配送中心提供安全、可持续制冷技术的前沿,帮助客户减少其设施的能源消耗和碳排放。
自动挤奶的最新发展引入了批量挤奶 – 一种在固定挤奶时间将奶牛分组挤奶的奶牛养殖实践,通常每天两次到三次。自动化技术正在帮助奶农克服近期的挑战,平衡奶牛场的奶牛福利、灵活性和可持续性,同时不断优化其成本结构并实现越来越高效的优势。
在许多国家/地区,获得安全用水和卫生设施体系仍然是一个挑战。由于饮用水不干净以及每天长途跋涉取水而生病,意味着许多儿童无法上学。GEA 通过与汉堡非营利组织 Viva con Agua 合作,使用一些非常神奇的技术帮助为坦桑尼亚的几所学校提供干净的水。