Liquid Dosage
Animal cell cultures
Cell culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. Cell cultures can be initiated from normal, embryonic or malignant tissue by aseptic collection from the animal host. In some cases, physical or enzymatic methods are used to disrupt the cells to prepare suspensions of single cells.
Animal cell culture technology has advanced significantly during the last few decades and is now generally considered to be a reliable, robust and relatively mature technology. A range of biotherapeutics is currently synthesized using cell culture methods in large-scale manufacturing facilities that produce products for both commercial use and clinical studies.
Using mammalian cell cultures, proteins can be produced in their effective form (quarternary structure). And, compared with microbial production in bacteria and yeasts, downstream processing is significantly reduced. In addition, infection risks in the production of human proteins can be avoided.
The robust implementation of mammalian cell technology requires a number of key variables to be optimized, including the culture media and bioreactor conditions, appropriate cell lines (CHO, BHK, hybrid and insect cells), low operating costs, high productivity rates, efficient process control and, above all, quality.
Successful implementation also requires appropriate strategies for process development, scale-up and characterization, and the validation of robust procedures that comply with current regulations.
Optimized Separation Processes
Particular attention must be paid to the effects of external influences such as shear forces on the behavior and productivity of the cells. The hydrohermetic inlet developed by GEA reduces shear forces to a minimum, an innovation that has been tested and published in co-operation with the University of Bielefeld (Germany).
As a competent manufacturer of complete plant for the life science industries, GEA is a full-service provider of solutions that meet your exact requirements and specifications. From planning, development and installation to qualification and maintenance, our experienced engineers will collaborate with your project team to supply innovative and efficient process solutions for your cell culture applications.
Prodotti e tecnologie
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Lyophilizers (Pharma Freeze Dryers)
GEA's thorough understanding of the lyophilization process enables them to supply a comprehensive range of products and services, comprising laboratory equipment, pilot plants for research and small-scale production batches, industrial size pharmaceutical production freeze dryers.
Machine automation & control
Every plant or machine, which is designed for a reliable long-term operation, requires a control unit that enables the communication between the different system parts. It is one of the most important component that guarantees reliability and efficient operation.
Pompe sanitarie
GEA Hilge offre una gamma versatile di pompe centrifughe e volumetriche per un'ampia varietà di applicazioni sensibili nell'industria delle bevande, alimentare e farmaceutica.
Separatore centrifugo
I separatori di GEA sono progettati per applicazioni a base liquida. Utilizzano la forza centrifuga per separare sospensioni composte da due o più fasi di densità diverse; possono cioè essere utilizzati per la separazione liquido-liquido, la separazione liquido-liquido-solido o la separazione liquido-solido. Separano miscele liquide con la stessa...
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Approfondimenti GEA
Zoccoli sani, animali più sani
Negli allevamenti vige una regola semplice ma fondamentale: gli zoccoli devono essere sani. Quando questo presupposto viene meno, le prestazioni, il benessere e l'efficienza ne risentono immediatamente, a prescindere da quanto all'avanguardia possa essere l'azienda.
GEA opens new technology center, strengthening its position in the growing pharmaceutical applications market
Together with Mona Neubaur, Minister of Economic Affairs of the German state of North Rhine-Westphalia, GEA CEO Stefan Klebert has opened a new technology center for pharmaceutical freeze-drying systems in Elsdorf, Germany. GEA employs approximately 260 people at the facility, which combines research and development with production and service under one roof.
