Fluid Bed Processing for Pharma Applications
FlexStream Fluid Bed Processor
FlexStream is a new multi-purpose processor that addresses the current shortfalls of traditional fluid bed processing, including linear scale-up, fully contained loading and unloading for Pharmaceutical applications.
Traditional Fluid Bed Technology
Fluid bed operations such as drying, granulation or particle coating are often major process steps in the production of solid dosage forms. And, even though the technology has been in use by pharmaceutical companies, globally, for more than 50 years, it has still a lot of shortfalls. Each unit operation needs dedicated machinery or process containers to achieve optimal performance. Another area of concern is scale-up, a task that is often complicated by different bed heights and inconsistencies between fluid bed processors. From a performance standpoint, granules produced by fluid bed granulation often show an excellent compression behaviour but can be weak and flow poorly (compared with high shear granulation). Some formulations can’t be granulated in a fluid bed at all, and coating applications based on conventional Wurster columns are subject to a number of drawbacks, such as scale-up issues, loss of coating material and agglomeration loses.
FlexStream Technology
Using proven GEA fluid bed technology to achieve fluid bed granulation, drying and pellet coating (or tablet coating) in a single module, FlexStream is a multipurpose processor that addresses the shortfalls of traditional fluid bed processing, including linear scale-up, fully contained loading and unloading, and superior product homogeneity for both LOD and PSD. Offering only one product container for all unit operations, the FlexStream reduces your build envelope (both height and footprint).
The FlexStream Concept
The FlexStream concept has the additional advantage that no mechanical adjustment is necessary to switch between using the equipment as a dryer, a granulator or a coater. And, impressive test data prove that, in addition to these commercial benefits, FlexStream gives superior product quality when compared with conventional top-spray granulation or Wurster coating.
Key Features
- WIP and CIP: Process optimisation depends on efficient, effective cleaning. Automation of the cleaning process ensures repeatability, allows validation and minimizes downtime.
- Rapid discharge using lean phase conveying system: enhanced by the Non-Sifting Gill Plate airflow from both above and below the air distributor is used to discharge the dry granules in a very efficient manner.
- Through-the-wall installation: ensures that all auxiliary equipment is housed outside the process room. This greatly simplifies GMP compliance.
- Solvent emission control: A range of open- and closed-cycle systems to remove or recover organic solvents is available.
- Spraying systems: Nozzles, pumps and liquid preparation units are supplied according to process needs.
Downloads
Produits associés
Traitement à lit fluidisé des produits pharmaceutiques
GEA fournit des systèmes de traitement à lit fluidisé (appelés fluid bed Multi-Processor™ aux États-Unis) pour le mélange, la granulation, le séchage, la pelletisation et l'enrobage pour l'industrie pharmaceutique.
Lit fluidisé R&D traitement des produits pharmaceutiques
Une gamme complète de technologies pour la recherche et le développement, conçue pour les applications à petite échelle. Elle couvre tous les aspects du dosage pharmaceutique à prise orale, les mélangeurs à fort taux de cisaillement, les sécheurs à lit fluidisé et les systèmes à enceinte unique pour la compression de comprimés, en passant par les...
PMA High Shear Processor
PMA Bottom-drive High Shear Granulators suitable for the high speed dispersion of dry powders, aqueous or solvent granulations, effervescent production and melt pelletization for Pharmaceutical applications.
Gral High Shear Granulators
Whether the customer’s requirement is for high shear mixing or granulation, GEA has a solution for every processing challenge and can help select the technology that is most suitable for your Pharma application.
GEA Insights
La biotech à l’épreuve du réel
Le nouveau Centre d’application et de technologie (ATC) GEA de Sarstedt, au sud de Hanovre, n’est ni un showroom ni un ersatz de laboratoire. C’est un lieu conçu pour les essais, la collecte de données et les décisions précoces. Un endroit où l’on détermine si un concept biologique peut devenir un procédé industriel robuste. Cette étape est plus importante qu’il n’y paraît.
L'évolution des emballages alimentaires en 4 tendances
Si le thermoformage joue depuis longtemps un rôle central dans le domaine de l'emballage alimentaire, il doit aujourd'hui affronter un tournant majeur. À une époque comme la nôtre où les réglementations se durcissent, où les matériaux évoluent et où les coûts augmentent, il ne suffit plus que les lignes de conditionnement FFS ou <i>Form-Fill-Seal</i> (Former-Remplir-Sceller) fonctionnent de manière fiable : elles sont désormais déterminantes pour garantir la fraîcheur des denrées, un prix accessible et la recyclabilité. Examinez de plus près les grandes tendances qui dans le domaine du thermoformage façonnent le secteur de l'emballage et de la distribution alimentaires.
