Animal cell culture technology has advanced significantly during the last few decades and is now generally considered to be a reliable, robust and relatively mature technology. A range of biotherapeutics is currently synthesized using cell culture methods in large-scale manufacturing facilities that produce products for both commercial use and clinical studies.
Using mammalian cell cultures, proteins can be produced in their effective form (quarternary structure). And, compared with microbial production in bacteria and yeasts, downstream processing is significantly reduced. In addition, infection risks in the production of human proteins can be avoided.
The robust implementation of mammalian cell technology requires a number of key variables to be optimized, including the culture media and bioreactor conditions, appropriate cell lines (CHO, BHK, hybrid and insect cells), low operating costs, high productivity rates, efficient process control and, above all, quality.
Successful implementation also requires appropriate strategies for process development, scale-up and characterization, and the validation of robust procedures that comply with current regulations.
Optimized Separation Processes
Particular attention must be paid to the effects of external influences such as shear forces on the behavior and productivity of the cells. The hydrohermetic inlet developed by GEA reduces shear forces to a minimum, an innovation that has been tested and published in co-operation with the University of Bielefeld (Germany).
As a competent manufacturer of complete plant for the life science industries, GEA is a full-service provider of solutions that meet your exact requirements and specifications. From planning, development and installation to qualification and maintenance, our experienced engineers will collaborate with your project team to supply innovative and efficient process solutions for your cell culture applications.
Продукты и технологии
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Hygienic pumps
GEA Hilge offers a versatile range of centrifugal and positive displacement pumps for a wide variety of sensitive applications in the beverage, food and pharmaceutical industries.
Lyophilizers (Pharma Freeze Dryers)
GEA's thorough understanding of the lyophilization process enables them to supply a comprehensive range of products and services, comprising laboratory equipment, pilot plants for research and small-scale production batches, industrial size pharmaceutical production freeze dryers.
Machine automation & control
Every plant or machine, which is designed for a reliable long-term operation, requires a control unit that enables the communication between the different system parts. It is one of the most important component that guarantees reliability and efficient operation.
Клапаны & компоненты для асептической обработки жидкости
Асептические клапаны удовлетворяют исключительно высокими требованиям, предъявляемым к сверхчистым (UltraClean) и асептическим (Aseptic) технологическим процессам. Вы можете быть уверены в том, что все они обеспечивают высочайшее качество с точки зрения гигиенического исполнения и долговечности.
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Аналитика GEA
Освоение искусства промышленного приготовления пищи: От преодоления сложностей к осуществлению контроля
Промышленное приготовление пищи не обязательно должно быть сложным. Откройте для себя стратегии и технологии, которые позволяют повысить уровень контроля, стабильность, эффективность и качество продуктов.
Формула воды
Засухи стали обычным явлением по всей Европе, и они уже не ограничиваются только южными регионами. Доступность воды во все большей степени определяет выбор места размещения промышленных предприятий, при этом ее ценность зависит от местных условий. Существует множество технологических путей повышения эффективности использования воды в промышленных процессах, при этом ключевыми факторами также являются местоположение, потребности в энергии и другие факторы.
