Liquid Dosage
Hormones & Steroids
Steroids, endogenous hormones such as the sex hormones estrogen and testosterone or the hormones of the adrenal cortex, cortisol and aldosterone, play a key role in metabolic processes and have a number of pharmaceutical applications, including hormone therapy, anti-rheumatic, anti-arthritic and bodybuilding preparations.
Mainly used in the global hormone replacement therapy, currently worth about $3.6 billion, the three major segments comprise estrogen, growth and thyroid hormone, and testosterone replacement therapy. A major market driver is the increased awareness of postmenopausal hazards amongst women; others include an ageing population, innovative drug delivery systems and the pharmerging economies.
Predominantly based on cholesterol, steroid hormones are synthesized in the endocrine glands and transported to target tissue by the blood. At their site of action, they dock with highly specific cellular receptors and perform a key function in protein formation. To produce steroid hormones for pharmaceutical applications outside the body, a direct extraction procedure from special nutrient solutions is used.
Counter-Current Liquid-Liquid Extraction
In continuous direct extraction from GEA, the fermented nutrient solution is treated by liquid-liquid extraction in a counter-current process. Following precipitation, concentration, crystallization and drying of the extract, the steroid hormones are available in the form of a raw salt and can be correspondingly processed by the pharmaceutical industry. In a continuous direct extraction process, the fermented nutrient solution undergoes a counter-current liquid-liquid extraction process (also known as also known as solvent extraction or partitioning). Following precipitation, concentration, crystallization and drying, the extracted steroid hormones are available in the form of a raw salt and can be subsequently processed by the pharmaceutical industry.
Fromfacility design and layout, manufacturing process controls (including adherence to standard operating procedures) and environmental control systems (HVAC) to extraction systems, industrial hygiene solutions and fully integrated, end-to-end containment solutions, GEA has the experience and know-how to implement and optimize end-to-end production lines for steroid- and hormone-based applications.
Productos y tecnologías
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Bombas higiénicas
GEA Hilge ofrece una gama versátil de bombas centrífugas y de desplazamiento positivo para una amplia variedad de aplicaciones sensibles en las industrias de bebidas, alimentaria y farmacéutica.
Lyophilizers (Pharma Freeze Dryers)
GEA's thorough understanding of the lyophilization process enables them to supply a comprehensive range of products and services, comprising laboratory equipment, pilot plants for research and small-scale production batches, industrial size pharmaceutical production freeze dryers.
R&D Drying Systems
GEA's versatile range of R&D drying & particle processing equipment - for advanced powder processing within food and dairy products, chemicals and pharmaceuticals.
Separador centrífugo
Los separadores de GEA están diseñados para aplicaciones a base de líquidos. Utilizan fuerza centrífuga y se emplean para separar suspensiones que consisten de dos o más fases de distinta densidad; por ejemplo, pueden separar líquido-líquido, líquido-líquido-sólido o líquido-sólido. También son eficaces para separar mezclas líquidas a la vez que ...
GEA Insights
Kytero 10 - los grandes cambios empiezan por lo pequeño
Con el GEA kytero 10, los investigadores y desarrolladores de las industrias biofarmacéutica, alimentaria y de nuevos alimentos tienen ahora a su disposición un potente acelerador de generación avanzada.
Cómo un robot de ordeño cambió la vida de una madre
La vida de Michele Schneider dio un giro inesperado cuando se casó con Virlei, un aspirante a ganadero, y ambos fundaron la explotación lechera Fazenda Inovação Schneider Milk en Brasil. Aunque era una recién llegada a la ganadería lechera, Michele vio crecer rápidamente su pasión por los animales y la granja. Y también su carga de trabajo.
En el menú: huevos más sostenibles
GEA ayuda a sus clientes a probar y escalar ovoproductos e ingredientes alternativos elaborados con fermentación de precisión.
