Liquid Dosage
Cell culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. Cell cultures can be initiated from normal, embryonic or malignant tissue by aseptic collection from the animal host. In some cases, physical or enzymatic methods are used to disrupt the cells to prepare suspensions of single cells.
Animal cell culture technology has advanced significantly during the last few decades and is now generally considered to be a reliable, robust and relatively mature technology. A range of biotherapeutics is currently synthesized using cell culture methods in large-scale manufacturing facilities that produce products for both commercial use and clinical studies.
Using mammalian cell cultures, proteins can be produced in their effective form (quarternary structure). And, compared with microbial production in bacteria and yeasts, downstream processing is significantly reduced. In addition, infection risks in the production of human proteins can be avoided.
The robust implementation of mammalian cell technology requires a number of key variables to be optimized, including the culture media and bioreactor conditions, appropriate cell lines (CHO, BHK, hybrid and insect cells), low operating costs, high productivity rates, efficient process control and, above all, quality.
Successful implementation also requires appropriate strategies for process development, scale-up and characterization, and the validation of robust procedures that comply with current regulations.
Particular attention must be paid to the effects of external influences such as shear forces on the behavior and productivity of the cells. The hydrohermetic inlet developed by GEA reduces shear forces to a minimum, an innovation that has been tested and published in co-operation with the University of Bielefeld (Germany).
As a competent manufacturer of complete plant for the life science industries, GEA is a full-service provider of solutions that meet your exact requirements and specifications. From planning, development and installation to qualification and maintenance, our experienced engineers will collaborate with your project team to supply innovative and efficient process solutions for your cell culture applications.
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GEA Hilge ofrece una gama versátil de bombas centrífugas y de desplazamiento positivo para una amplia variedad de aplicaciones sensibles en las industrias de bebidas, alimentaria y farmacéutica.
GEA's thorough understanding of the lyophilization process enables them to supply a comprehensive range of products and services, comprising laboratory equipment, pilot plants for research and small-scale production batches, industrial size pharmaceutical production freeze dryers.
Every plant or machine, which is designed for a reliable long-term operation, requires a control unit that enables the communication between the different system parts. It is one of the most important component that guarantees reliability and efficient operation.
Los separadores de GEA están diseñados para aplicaciones a base de líquidos. Utilizan fuerza centrífuga y se emplean para separar suspensiones que consisten de dos o más fases de distinta densidad; por ejemplo, pueden separar líquido-líquido, líquido-líquido-sólido o líquido-sólido. También son eficaces para separar mezclas líquidas a la vez que ...
La demanda de café aumenta con rapidez. Descubra cómo la tecnología de extracción continua de GEA aumenta el rendimiento, preserva el sabor y ahorra recursos.
El impacto del calentamiento global es cada vez más evidente en todo el mundo. Los pueblos y ciudades de todo el mundo se enfrentan al mismo reto: proporcionar a sus comunidades una calefacción fiable, asequible y de origen sostenible. GEA habló con un experto en la materia, Kenneth Hoffmann, director de bombas de calor de GEA Heating & Refrigeration Technologies, sobre cómo atajar con más rapidez el calentamiento global.
Algo llamó la atención del granjero Tom. En lugar de otra demostración de producto, GEA mostró innovaciones por medio de realidad aumentada. Eso es solo el principio de la granja digital interactiva de GEA.