Liquid Dosage
Inhalable Suspension
Inhalation is often the preferred drug delivery method for lung diseases, offering a number of advantages for both patients and medical professionals for the administration of vaccines and other biological drugs.
The active ingredient of many inhalable products, such as anti-asthma medications, acts on the muscle cells of the pulmonary airways. Such medications can be rendered inefficient, however, if particles aggregate in the inhaler. In addition, to prevent dry powder aerosols from depositing particulate matter in the oropharyngeal cavity — and in the inhaler — dispensed particles should have a geometric diameter of 1–3 µm and a mass density of approximately 1 g/cm3.
Inhaled drugs are usually dissolved in an aqueous system, such as an isotonic salt solution, and aerosolized at a high pressure to obtain nebulized particles. The liquid solution is pumped through a homogenizing valve at 500–1000 bar, using a single stage process, during which semi-solid particles become dispersed in the liquid.
The high-pressure homogenization enables the size reduction of average to large particles and makes the suspension more stable as a result of the decreased sedimentation rate. Moreover, it eliminates biological risk and provides better tolerance to irritants, as well as improving the clarity and transparency of the processed product.
In addition to a comprehensive range of homogenizers, GEA also offers production-scale mixing, blending, spray drying and micronization solutions for the manufacture of inhalable products, plus an unparalleled level of expertise in the design and layout of suitable plant: from vessel size dimensions to valves and 3D P&IDs, and from R&D to full-scale production.
Productos y tecnologías
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Bloque de compresión del homogeneizador
Los cabezales de compresión de GEA son el elemento central del homogeneizador puesto que bombean el producto a alta presión hasta que fluye por el interior de la válvula de homogeneización y de esta forma activan el proceso de homogeneización.
Clarificador
El separador clarificador centrífugo se utiliza para separar sólidos de líquidos. El separador incorpora discos cónicos apilados para crear una gran zona de aclarado dentro de un tambor que tiene un volumen relativamente pequeño.
Dispositivos de análisis, control en línea y medición
La combinación del control de los procesos mediante analizadores en línea con principios de ingeniería de procesos sólidos y técnicas avanzadas de modelización de procesos permitirá controlar los procesos de forma activa para compensar las variaciones de entrada.
GEA Varipump
The pump models in the GEA Varipump line are conceived for extreme application demands and are individually optimized for your task.
GEA Insights
Preparar la cadena de frío para el futuro con una refrigeración sostenible
No se puede subestimar la importancia de una gestión de calidad de la cadena de frío. Garantizar que los alimentos perecederos sean seguros en el punto de consumo es una enorme responsabilidad para quienes gestionan las instalaciones...
