Solid Dosage
Inhalable fine powders
GEA supplies highly specialized solutions for manufacturing inhalable drugs ranging from dry powder blending, spray drying to particle engineering capabilities.
Inhalable Fine Powder Processing for Pharmaceutical Drug Dosage Forms
Inhalables and aerosols, no matter whether they are in liquid or solid form, must be delivered to the oral cavity or the greater respiratory system.
Inhalation is often the preferred drug delivery method for lung diseases, offering a number of advantages for both patients and medical professionals for the administration of vaccines and other biological drugs. Producing powders for inhalation is relatively straightforward on a small scale; but, it can be hard to replicate at a commercial level.
To facilitate the process, GEA has developed a highly specialized spray drying system that offers large-scale particle engineering capabilities. This makes it possible to accurately manipulate the aerodynamic size and flow properties of particles to produce fine, free-flowing powders for applications such as commercializing biological compounds including hormones, peptides and proteins that risk degradation if ingested.
When it comes to mixing and blending very fine powders, homogeneity and stability are key factors during the production of inhalable drugs. As such, GEA also offers production-scale mixing and blending solutions to produce inhalable products (dry powders and suspensions).
The TRV high-speed blender, a standalone PharmaConnect® module, is particularly suitable for the rapid batch blending of small quantities of APIs with base excipients. By combining the high surface area of the main impeller blade with the directional effects of the feeder blade, rapid, homogenous and stable blends can be produced in a reproducible manner.
Products & Technologies
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Analytical, in-line control & measurement devices
Combining process monitoring using online analyzers, together with solid process engineering principles and advanced process modelling techniques will enable processes to be actively controlled in order to compensate for input variations.
CIP/SIP Solutions
Innovative CIP concepts of GEA meet comprehensive high standards. Our experts guarantee product safety at every point of the process. Every upgrade is adapted to individual local conditions and customer requirements and leads to noticeable savings.
Contained Materials Handling Systems
Contained Materials Handling solutions for Primary and Secondary Pharmaceuticals and Healthcare. With extensive experience within the generics sector, supply a wide range of technologies and equipment that improve and enhance the efficiency and performance of Oral Solid Dosage production.
Continuous Direct Compression Line
The ConsiGma® DC for direct compression is the latest expansion of GEA's continuous portfolio for cost effective, compact, high yield manufacturing systems. It offers a robust and flexible manufacturing method for a wide range of products.
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