CIP/SIP Solutions

Cleaning-In-Place and Sterilizing-In-Place systems are an essential part of every quality-conscious manufacturing of pharmaceutical products.

GEA provides high-performance cleaning and sterilisation concepts that are individually adapted to the client's very specific requirements.

GEA verifies whether one or several CIP cleaning vessels are required to achieve the maximum cleaning effect for each plant. The cleaning steps are specifically configured under consideration of the kind of product to be manufactured.

From mobile or stationary cleaning systems up to CIP satellites fed with conditioned cleaning media from a central unit – the variety of special solutions for your process plant is vast.  Prerequisite for the manufacture of sterile liquid pharmaceutical products is that loop and machine systems are kept sterile. It is imperative that all equipment coming into contact with the product must be subjected to a documented temperature-controlled sterilisation procedure with hot media.

Sterile production requires sterile plants. In the pharmaceutical industry, sterilizing in place is done in almost all cases by using saturated steam at a pressure of 1 bar. After sterilisation, a system in contact with steam has to be cooled down. This is done by means of blowing out the system with sterile air and, in case of process vessels, the cooling system via the jacket is activated.

Having ended the SIP process, all sensitive components have to be checked for their proper functionality and integrity. This is most important in the case of filters that have been used for a sterile filtration.

GEA has extensive experience with sterile processes for almost every task. Safe production lines and safe connection points to the related process or filling machines along with an efficient and time-saving procedure are of vital importance.