菜单

ConsiGma™

ConsiGma® Tablet Coating (TC) Modules

许多片剂配方都要求在压片后进行包衣,以达到所需的最终产品特性。为完善 ConsiGma™ 压片生产线,GEA 开发了可以支持其连续制造概念的包衣机。

ConsiGma 包衣机

ConsiGma™ 包衣机是一款高速的鼓式包衣机,其尺寸和设计都是为了能成为集成式压片解决方案的一部分。它可以使用水基和溶剂基的悬浮液来制作装饰性和功能性包衣。可以根据生产线的实际生产能力(公斤/小时)来调整鼓数。还可以对它进行离线清洗 (WOL),以极快的速度完成更换。

概念

ConsiGma™ 包衣机是一种革命性的新型高性能片剂包衣技术,可精确地将受控数量的包衣材料沉积在片剂上,即使是吸湿或易碎的片剂也能处理。包衣机是为 ConsiGma™ 连续高速剪切造粒、压片和干燥系统专门设计的组成部分,这种开创性的机器能够以非常高的速度为少量片剂包衣,并提供改进的热量和质量传递,同时使用远少于传统技术的包衣材料。

这种新型包衣机带来片剂包衣技术的根本性改变,将片剂置于级联片剂运动中,比传统包衣盘带来更高的液体涂敷速率(意味着更高的包衣形成速度)。它还兼容 PAT,效率高(预热和干燥时间比常规包衣机更短)并且可靠,使片剂增重和包衣分布一致、均质且均匀。而且,由于包衣机的运行速度和温度高于市场上的其他产品,因此可获得更高的喷涂速率和改进的片剂混合效果,这将其应用潜力扩大到聚合物包衣,并超越目前可能实现的功能。该设备甚至可以用来在包衣之前为片剂药芯除尘。

这一小型 ConsiGma™ 包衣机使包衣桶内的片剂作更多的运动,拥有革命性的设计,并应用了增强的工艺条件,因此浓缩了片剂包衣工艺,带来更快的处理速度、更多时间和成本节约、更高的效率以及更好的成品质量,所有这些都是推进连续加工技术进步的基本方面。

关键特征

  • 活塞流/先进先出原则:对包衣工艺实施同样的 Consigma™ 活塞流理念。这样,可在整个加工过程中全面、可靠地跟踪产品。
  • 加工时间短,只需几分钟。对于 3 公斤的片剂装载,完整的包衣循环名义上需要 6-8 分钟。
  • 无需扩展。研发和生产中使用相同的包衣机
  • 工艺轻柔。这款设备既能加工少量片剂,加工时间又短,因此适合为非常柔软的片剂包衣。

相关产品

CIP for Pharmaceutical Process Plants

CIP for Pharmaceutical Process Plants

Process optimisation depends on efficient, effective cleaning. Clean-in-Place (CIP) systems can be incorporated into all the equipment produced by GEA for the pharmaceutical industry, including fluid bed dryers, high-shear granulators and liquid dosage formulation systems. Automating the cleaning process ensures repeatability, allows validation and minimizes downtime.

ConsiGma® Direct Compression with Linear Blending (DC-LB) Lines

ConsiGma® Direct Compression with Linear Blending (DC-LB) Lines

A highly integrated solution for continuous linear blending and direct compression, the ConsiGma® DC-LB lines offer all the advantages of continuous manufacturing: supply chain agility, small footprint, controlled blending and compression and improved quality.

ConsiGma® Granulation and Compression (GC) Lines

ConsiGma® Granulation and Compression (GC) Lines

Highly integrated solutions for continuous wet granulation, drying and tablet compression, the ConsiGma® GC lines offer all the advantages of continuous manufacturing: supply chain agility, small footprint, controlled granulation and improved quality.

Lighthouse Probe™ - online measurement

Lighthouse Probe™ - online measurement

The Lighthouse Probe™ can be used for real-time monitoring of chemical and pharmaceutical processes and provides in-process window cleaning at any time, recalibration during the process, full CIP (cleaning) of wash housing and seal, and a clear view inside – even in difficult conditions.

Wash-Off-Line for Pharmaceutical Plants

Wash-Off-Line for Pharmaceutical Plants

In addition to providing complete containment services, GEA also offers multifunctional wash skids that can be moved from one location to another and used to clean different parts of the process. Every plant delivered by GEA has a tailor made CIP, WIP or Wash-Off-Line (WOL) system to suit your application.

用于制药公司研发过程的连续工艺

用于制药公司研发过程的连续工艺

在早期研究和配方开发期间,活性成分的可用性通常十分有限,因此要求加工设备可以只生产几百克的产品供开发新药品配方使用。为了响应这种需求,GEA 开发出了 ConsiGma™ 1,这是 ConsiGma™ 概念的实验室规模版本。

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