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ConsiGma®

ConsiGma® Granulation and Compression (GC) Lines

Highly integrated solutions for continuous wet granulation, drying and tablet compression, the ConsiGma® GC lines offer all the advantages of continuous manufacturing: supply chain agility, small footprint, controlled granulation and improved quality.

Continuous Line

ConsiGma® GC Lines integrate continuous wet granulation, fluid bed drying and tablet compression into one efficient continuous production system.

Available in 3 standard sizes, depending on the desired throughput (from 5 to 120 kg/h or 20,000 to 180,000 tablets/h to be verified by testing), the systems can be customized with a number of options to suit customer needs.

The Conductor 4.0 software ensures seamless control of the entire process and provides full reporting and track & trace.

Mainly targeted towards high value products (low dose API), orphan drugs and new chemical entities, the systems can be equipped with cleaning and containment features to handle highly potent formulations.

Standard Configuration

  • 1 loss-in-weight feeder for formulation pre-mix
  • Twin-screw granulator
  • Segmented fluid bed dryer
  • Granule conditioning unit
  • GEA compression system

Available Options

  • Dosing and blending unit for preparing the formulation pre-mix
  • Melt granulation set-up
  • Solvent capable
  • PSR
  • PAT tools
  • Cleaning upgrade
  • Containment upgrade
  • Material handling system including containment features
  • TC coater modules

Main Benefits

  • Controlled granulation
    • Better distribution of granulation binder
    • Porosity control of the granules  
    • Control of granule particle size distribution
  • Small amount of product in process (minimal amount of API at risk of OOS)
  • Elimination of work-in-progress
  • Increased flexibility from very low to very high API content 
  • Use of solvent-free binders
  • Compatible with variable throughput capacities
  • Flexible batch size
  • Smaller footprint

相关产品

CIP for Pharmaceutical Process Plants

CIP for Pharmaceutical Process Plants

Process optimisation depends on efficient, effective cleaning. Clean-in-Place (CIP) systems can be incorporated into all the equipment produced by GEA for the pharmaceutical industry, including fluid bed dryers, high-shear granulators and liquid dosage formulation systems. Automating the cleaning process ensures repeatability, allows validation and minimizes downtime.

ConsiGma® Direct Compression with Linear Blending (DC-LB) Lines

ConsiGma® Direct Compression with Linear Blending (DC-LB) Lines

A highly integrated solution for continuous linear blending and direct compression, the ConsiGma® DC-LB lines offer all the advantages of continuous manufacturing: supply chain agility, small footprint, controlled blending and compression and improved quality.

ConsiGma® Tablet Coating (TC) Modules

ConsiGma® Tablet Coating (TC) Modules

许多片剂配方都要求在压片后进行包衣,以达到所需的最终产品特性。为完善 ConsiGma™ 压片生产线,GEA 开发了可以支持其连续制造概念的包衣机。

Lighthouse Probe™ - online measurement

Lighthouse Probe™ - online measurement

The Lighthouse Probe™ can be used for real-time monitoring of chemical and pharmaceutical processes and provides in-process window cleaning at any time, recalibration during the process, full CIP (cleaning) of wash housing and seal, and a clear view inside – even in difficult conditions.

MODUL™ Tablet Press Technology

MODUL™ Tablet Press Technology

All MODUL™ tablet presses are based on the Courtoy™ Exchangeable Compression Module (ECM) concept. The ECM is completely isolated from the remainder of the machine, contains all product contact parts and can easily be removed from the press in a contained way. This means that the press itself remains powder-free and requires no cleaning.

Wash-Off-Line for Pharmaceutical Plants

Wash-Off-Line for Pharmaceutical Plants

In addition to providing complete containment services, GEA also offers multifunctional wash skids that can be moved from one location to another and used to clean different parts of the process. Every plant delivered by GEA has a tailor made CIP, WIP or Wash-Off-Line (WOL) system to suit your application.

用于制药公司研发过程的连续工艺

用于制药公司研发过程的连续工艺

在早期研究和配方开发期间,活性成分的可用性通常十分有限,因此要求加工设备可以只生产几百克的产品供开发新药品配方使用。为了响应这种需求,GEA 开发出了 ConsiGma™ 1,这是 ConsiGma™ 概念的实验室规模版本。

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