菜单

ConsiGma®

ConsiGma® Direct Compression with Linear Blending (DC-LB) Lines

A highly integrated solution for continuous linear blending and direct compression, the ConsiGma® DC-LB lines offer all the advantages of continuous manufacturing: supply chain agility, small footprint, controlled blending and compression and improved quality.

Pharma Technology Compression

ConsiGma® DC-LB Lines integrate continuous dry blending using linear blenders and tablet compression into one efficient continuous production system.

Available in 2 standard sizes, depending on the desired throughput (from 1 to 100 kg/h or 20,000 to 150,000 tablets/h to be verified by testing), the systems can be customized with a number of options to suit customer needs.

The Conductor 4.0 software ensures seamless control of the entire process and provides full reporting and track & trace.

Mainly targeted towards high-value products (low dose API), orphan drugs and new chemical entities, and particularly suited for challenging recipes that require two-stage blending or more dispersive blending, the systems can be equipped with cleaning and containment features to handle highly potent formulations.

Standard Configuration

  • Up to 6 loss-in-weight feeders with automatic top-up systems

  • 2 linear blenders

  • GEA compression system

Available Options

  • PAT tools

  • Hot swap parts for fast changeover

  • Material handling system including containment features

  • Containment upgrade

  • Coater

Main Benefits

  • Reduced risk of segregation – no material hold-ups

  • Highest possible blend homogeneity – all powder particles go through the same mixing event

  • Higher material yield

  • High flexibility from very low to very high API content

  • In process blend uniformity control – second-by-second

  • Adaption to variable throughput capacities

  • No hold-up issues

  • Wider drug load range than batch processing

  • System automatically adapts to changes in bulk density

  • Adaptable top-up sizes to ensure accurate feeding

  • Automatically adjustable dwell time

  • Flexible batch size

  • Smaller footprint

相关产品

CIP for Pharmaceutical Process Plants

CIP for Pharmaceutical Process Plants

Process optimisation depends on efficient, effective cleaning. Clean-in-Place (CIP) systems can be incorporated into all the equipment produced by GEA for the pharmaceutical industry, including fluid bed dryers, high-shear granulators and liquid dosage formulation systems. Automating the cleaning process ensures repeatability, allows validation and minimizes downtime.

ConsiGma® Granulation and Compression (GC) Lines

ConsiGma® Granulation and Compression (GC) Lines

Highly integrated solutions for continuous wet granulation, drying and tablet compression, the ConsiGma® GC lines offer all the advantages of continuous manufacturing: supply chain agility, small footprint, controlled granulation and improved quality.

ConsiGma® Tablet Coating (TC) Modules

ConsiGma® Tablet Coating (TC) Modules

许多片剂配方都要求在压片后进行包衣,以达到所需的最终产品特性。为完善 ConsiGma™ 压片生产线,GEA 开发了可以支持其连续制造概念的包衣机。

Lighthouse Probe™ - online measurement

Lighthouse Probe™ - online measurement

The Lighthouse Probe™ can be used for real-time monitoring of chemical and pharmaceutical processes and provides in-process window cleaning at any time, recalibration during the process, full CIP (cleaning) of wash housing and seal, and a clear view inside – even in difficult conditions.

Wash-Off-Line for Pharmaceutical Plants

Wash-Off-Line for Pharmaceutical Plants

In addition to providing complete containment services, GEA also offers multifunctional wash skids that can be moved from one location to another and used to clean different parts of the process. Every plant delivered by GEA has a tailor made CIP, WIP or Wash-Off-Line (WOL) system to suit your application.

用于制药公司研发过程的连续工艺

用于制药公司研发过程的连续工艺

在早期研究和配方开发期间,活性成分的可用性通常十分有限,因此要求加工设备可以只生产几百克的产品供开发新药品配方使用。为了响应这种需求,GEA 开发出了 ConsiGma™ 1,这是 ConsiGma™ 概念的实验室规模版本。

GEA观点

即刻注册,随时掌握GEA创新技术和精彩讯息

注册

我们随时为您提供帮助!您只需提供少量详细信息,我们就能回复您的查询。

联系我们