Fluid Bed Processing for Pharma Applications
FlexStream Fluid Bed Processor
FlexStream is a new multi-purpose processor that addresses the current shortfalls of traditional fluid bed processing, including linear scale-up, fully contained loading and unloading for Pharmaceutical applications.
Traditional Fluid Bed Technology
Fluid bed operations such as drying, granulation or particle coating are often major process steps in the production of solid dosage forms. And, even though the technology has been in use by pharmaceutical companies, globally, for more than 50 years, it has still a lot of shortfalls. Each unit operation needs dedicated machinery or process containers to achieve optimal performance. Another area of concern is scale-up, a task that is often complicated by different bed heights and inconsistencies between fluid bed processors. From a performance standpoint, granules produced by fluid bed granulation often show an excellent compression behaviour but can be weak and flow poorly (compared with high shear granulation). Some formulations can’t be granulated in a fluid bed at all, and coating applications based on conventional Wurster columns are subject to a number of drawbacks, such as scale-up issues, loss of coating material and agglomeration loses.
FlexStream Technology
Using proven GEA fluid bed technology to achieve fluid bed granulation, drying and pellet coating (or tablet coating) in a single module, FlexStream is a multipurpose processor that addresses the shortfalls of traditional fluid bed processing, including linear scale-up, fully contained loading and unloading, and superior product homogeneity for both LOD and PSD. Offering only one product container for all unit operations, the FlexStream reduces your build envelope (both height and footprint).
The FlexStream Concept
The FlexStream concept has the additional advantage that no mechanical adjustment is necessary to switch between using the equipment as a dryer, a granulator or a coater. And, impressive test data prove that, in addition to these commercial benefits, FlexStream gives superior product quality when compared with conventional top-spray granulation or Wurster coating.
Key Features
- WIP and CIP: Process optimisation depends on efficient, effective cleaning. Automation of the cleaning process ensures repeatability, allows validation and minimizes downtime.
- Rapid discharge using lean phase conveying system: enhanced by the Non-Sifting Gill Plate airflow from both above and below the air distributor is used to discharge the dry granules in a very efficient manner.
- Through-the-wall installation: ensures that all auxiliary equipment is housed outside the process room. This greatly simplifies GMP compliance.
- Solvent emission control: A range of open- and closed-cycle systems to remove or recover organic solvents is available.
- Spraying systems: Nozzles, pumps and liquid preparation units are supplied according to process needs.
Downloads
Produtos relacionados
Processamento de farmacêuticos em leito fluidizado
A GEA fornece os processadores de leito fluidizado (conhecidos como Multi-Processor™ de leito fluidizado nos EUA) para a mistura, granulação, secagem, peletização e revestimento para a indústria farmacêutica.
Processamento de farmacêuticos de P&D em leito fluidizado
Uma gama completa de tecnologias para R & D projetadas para aplicações específicas, a nossa gama de pequena escala cobre todos os aspectos da produção farmacêutica de dosagem sólida oral, desde misturadores de alto cisalhamento, secadores de leito fluidizado e sistemas de vaso único, a extrusadoras e esferonizadoras, misturadores e soluçõ...
PMA High Shear Processor
PMA Bottom-drive High Shear Granulators suitable for the high speed dispersion of dry powders, aqueous or solvent granulations, effervescent production and melt pelletization for Pharmaceutical applications.
Gral High Shear Granulators
Whether the customer’s requirement is for high shear mixing or granulation, GEA has a solution for every processing challenge and can help select the technology that is most suitable for your Pharma application.
Insights da GEA
Shifts in food packaging: 4 trends
Thermoforming has long played a central role in food packaging. Now it is facing a major shift. As regulations tighten, materials evolve and costs rise, form fill seal lines must do more than run reliably – they now shape how food stays fresh, affordable and recyclable. Take a look at the key thermoforming trends informing the food packaging and delivery landscape.
Armazenamento de frutas na Betko: Controle desde o pico da colheita até a distribuição global
Dos pomares do Cabo às prateleiras de lojas em 40 países, a empresa sul-africana de armazenamento Betko construiu seu negócio com base no frescor, no timing e na confiabilidade. Com a tecnologia de refrigeração em atmosfera controlada da GEA, a empresa agora pode conservar maçãs e peras por até 14 meses e reduzir o consumo de energia em 20%, graças a uma parceria de mais de 30 anos que está no centro de tudo isso.
