Fluid Bed Processing for Pharma Applications
FlexStream™ Fluid Bed Processor
FlexStream™ is a new multi-purpose processor that addresses the current shortfalls of traditional fluid bed processing, including linear scale-up, fully contained loading and unloading for Pharmaceutical applications.
FlexStream™ is a new multi-purpose processor that addresses the current shortfalls of traditional fluid bed processing, including linear scale-up, fully contained loading and unloading for Pharmaceutical applications.
Fluid bed operations such as drying, granulation or particle coating are often major process steps in the production of solid dosage forms. And, even though the technology has been in use by pharmaceutical companies, globally, for more than 50 years, it has still a lot of shortfalls. Each unit operation needs dedicated machinery or process containers to achieve optimal performance. Another area of concern is scale-up, a task that is often complicated by different bed heights and inconsistencies between fluid bed processors. From a performance standpoint, granules produced by fluid bed granulation often show an excellent compression behaviour but can be weak and flow poorly (compared with high shear granulation). Some formulations can’t be granulated in a fluid bed at all, and coating applications based on conventional Wurster columns are subject to a number of drawbacks, such as scale-up issues, loss of coating material and agglomeration loses.
Using proven GEA fluid bed technology to achieve fluid bed granulation, drying and pellet coating (or tablet coating) in a single module, FlexStream™ is a new multipurpose processor that addresses the current shortfalls of traditional fluid bed processing, including linear scale-up, fully contained loading and unloading, and superior product homogeneity for both LOD and PSD. Offering only one product container for all unit operations, the FlexStream™ reduces your build envelope (both height and footprint) and provides PAT-compatible in-line particle growth measurement.
Whether the customer’s requirement is for high shear mixing or granulation, GEA has a solution for every processing challenge and can help select the technology that is most suitable for your Pharma application.
PMA™ High Shear and PMA-Advanced™ Mixer and Granulator is a multipurpose processor that's equally suitable for the high speed dispersion of dry powders, aqueous or solvent granulations, effervescent production and melt pelletization for Pharma applications.
Uma gama completa de tecnologias para R & D projetadas para aplicações específicas, a nossa gama de pequena escala cobre todos os aspectos da produção farmacêutica de dosagem sólida oral, desde misturadores de alto cisalhamento, secadores de leito fluidizado e sistemas de vaso único, a extrusadoras e esferonizadoras, misturadores e soluções da contenção até a compressão do tablete.
A GEA fornece os processadores de leito fluidizado (conhecidos como Multi-Processor™ de leito fluidizado nos EUA) para a mistura, granulação, secagem, peletização e revestimento para a indústria farmacêutica.
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