Continuous Processing Lines for Pharma
A Continuous process is a process where raw materials are continuously fed into a system at the same time as finished product is continuously removed at the end of the process train. The raw materials are processed in very small quantities, compared to batch processes, and in a controlled manner, which allows the operator to have consistent control over the critical process parameters and therefore the critical product quality attributes.
At GEA, we believe that continuous processing improves the quality of pharmaceutical end products: by focusing on quality during the whole product lifecycle, not just “tested in” quality; and by understanding the capability of your processes, managing sources of variability and decreasing any associated risks.
Our solution for continuous drying and particle processing plants is ConsiGma®, a 6 sigma-inspired manufacturing platform, incorporating different technologies to produce oral solid dosage forms in a continuous, cost-efficient way:
- by collecting more information during R&D phase, in a short time with less product
- by excluding risky, time- and product consuming scale-up exercises
- by introducing online measurement and closed loop control targeting real-time release (6 sigma production)
- by incorporating flexible batch size (JIT production), reducing inventory
- by reducing the energy cost per tablet, reducing environmental impact.
Products
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ConsiGma® 1 - R&D Granulation and Drying
The ConsiGma® 1 offers standalone continuous twin-screw granulation and drying for small-scale R&D operations. It allows users to develop the process and achieve high granule quality on a compact unit.
ConsiGma® Conductor
An indispensable part of the ConsiGma portfolio, the Conductor control system architecture ensures smooth operation and communication between the different elements of a pharmaceutical continuous manufacturing line
ConsiGma® Direct Compression with Linear Blending (DC-LB) Lines
A highly integrated solution for continuous linear blending and direct compression, the ConsiGma® DC-LB lines offer all the advantages of continuous manufacturing: supply chain agility, small footprint, controlled blending and compression and improved quality.
ConsiGma® Direct Compression with Ribbon Blending (DC-RB) Lines
A cost-effective solution for continuous dry blending and tablet compression using ribbon blending, ConsiGma® DC-RB lines make the advantages of continuous manufacturing (supply chain agility, small footprint and improved quality) available for all.
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Approfondimenti GEA
GEA reports profitable growth for 2025 and expects accelerated revenue growth
GEA’s past fiscal year was one of significant growth and further profitability gains. In particular, the technology group substantially increased order intake, with all divisions contributing here. GEA also made progress in all Mission 30 strategic growth areas. In addition, GEA met key interim targets under its climate plan ahead of schedule. Major milestones in fiscal year 2025 were admission to the DAX index, the award of one of the largest contracts in the company’s history, and streamlining of the corporate structure.
Come SmartParc sta riscrivendo le regole della produzione alimentare
Grazie al nuovo sito produttivo SmartParc, le aziende di trasformazione alimentare del Regno Unito stanno riducendo i costi operativi e le emissioni. Basato sulla tecnologia di riscaldamento e raffreddamento GEA, questo modello di produzione collaborativo dimostra come l'innovazione stia accelerando le ambizioni di azzeramento delle emissioni nette del settore.
Il laboratorio di scienze alimentari
"Fare le uova come la birra". Un paragone che prima fa sorridere e poi riflettere: in effetti è il modo più semplice per spiegare qualcosa di molto complesso. Attraverso questo breve filmato girato nel cuore agricolo degli Stati Uniti, scopriamo la fermentazione di precisione e il lavoro concreto necessario per trasformare un'idea in cibo.
