Comunicato stampa commerciale
GEA builds process plant for the production of immunoglobulin for CSL Behring in Bern
13 Aug 2020
"PROTINUS" (lat. forward, further") is the name of the project with which the biopharmaceutical company CSL Behring will significantly increase the production capacity of immunoglobulin at its site. GEA received the order for the process plant, the heart of the facility.
Based on previous collaborations, GEA Group's comprehensive range of plant and components helped CSL Behring to increase its production capacity for life-saving immunoglobulins during Project "PROTINUS". (Photo: BLICKPUNKT PHOTODESIGN, Daniel Bödeker)
The two additional production lines will enable a further 90,000 patients per year to be supplied with life-saving drugs. Thanks to the good cooperation of all parties involved in the project, it was possible to continue the project on schedule despite the global corona pandemic. Following the successful commissioning of the modules I and II also in Berne, Switzerland (2007 and 2009) and modules III and IV at CSL Behring's Melbourne, Australia site (2013 and 2017), this is now the third GEA process plant at CSL Behring to be commissioned with modules V and VI.
High demands on plants and process safety
CSL Behring relied on GEA not only because of the good experience with the previous projects in Berne and Melbourne. As a supplier of sterile process plants with many years of experience, GEA can draw on the extensive theoretical knowledge and professional competence of its engineers to provide modern, customized and cost-efficient process lines for the production of new drugs in accordance with the current requirements of the global drug regulatory authorities. The technological competence for the biotechnology industry includes cultivation, fermentation, separation, homogenization, crystallization, concentration, freeze drying and fractionation, complemented by a comprehensive range of bioreactors, fermenters, vessels and high-quality components. GEA plants are also characterized by high availability and economical operation. This is backed up by a long history, combined with a great deal of competence and experience in this field. In fact, the first pharmaceutical plant was built back in the 1970s. Since the 1980s the company has strategically focused on biopharmaceutical applications.
Recipe for success: Integration in the engineering process and continuous improvements
The "PROTINUS" project in Berne had other success factors. For example, GEA was able to build on the many years of experience gained with the running plants in Berne and Melbourne. This was another reason why GEA was involved in the engineering process from the very beginning. Together with CSL Behring, GEA continued to work on the degree of automation and took it to new levels. Significant progress was made in the areas of "increased availability", "operability" and "safety". A concrete example: As an improvement on the previous modules, a purely manual switchover panel could be replaced by a complex valve combination in the clean room. This allows CIP cleaning and product transfer without risk of contamination in parallel and without manual operator actions.
Immunoglobulin - life saver for many people and the possibility to lead a normal life again
"Our greatest incentive in this project is that the additional production capacity will enable around 90,000 people per year to lead a normal life," says Pierre Caloz, Head of Manufacturing EU & APAC, CSL Behring. CSL Behring has therefore invested 250 million Swiss francs in the project, creating 50 new jobs. Immunoglobulins are proteins of the globulin class. They are used to defend the human organism against foreign substances that have entered the body. They therefore play a central role in the immune defense. They are used in autoimmune diseases as well as in passive immunization against certain pathogens and in cancer therapy.
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About GEA
GEA is one of the world’s largest suppliers of systems and components to the food, beverage and pharmaceutical industries.
The international technology group, founded in 1881, focuses on machinery and plants, as well as advanced process technology, components and comprehensive services. For instance, every second pharma separator for essential healthcare products such as vaccines or novel biopharmaceuticals is produced by GEA. In food, every fourth package of pasta or every third chicken nugget are processed with GEA technology.
With more than 18,000 employees, the group generated sales of about EUR 5.5 billion in more than 150 countries in the 2025 fiscal year. GEA plants, processes, components and services enhance the efficiency and sustainability of customers’ production. They contribute significantly to the reduction of CO2 emissions, plastic usage and food waste. In doing so, GEA makes a key contribution toward a sustainable future, in line with the company’s purpose: ”Engineering for a better world.”
GEA is listed on the German MDAX, the European STOXX® Europe 600 Index and is also a constituent of the leading sustainability indices DAX 50 ESG, MSCI Global Sustainability and Dow Jones Best-in-Class World.
