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R&D Solutions for Batch and Continuous Solid Dosage Processing

11 Jun 2018

Designed for a broad array of applications, our R&D range covers every aspect of oral solid dosage production, from high shear mixers, fluid bed dryers and single pot systems to extruders and spheronizers, blenders and containment solutions, right through to tablet compression. We believe that by continually stretching the boundaries of pharmaceutical processing, we can help our customers to enhance the health and well-being of millions of people all over the world.

R&D Solutions for Batch and Continuous Solid Dosage Processing

Compression

Always looking to improve the research, development and scale-up process for oral solid dosage forms, we’re currently working on a compaction data acquisition and analysis system (CDAAS). Comprising mechanical components (feeders, hoppers and tooling), electrical elements and a software package, the CDAAS makes it possible to do formulation development work on a production-scale machine using minute amounts of product.

With this new kit, just 50  g of product is enough to proceed with the fundamental characterization of the compression process on a commercial-scale rotary tablet press. Test sequences can be generated with multiple runs to optimize the press parameters. Loaded into the MC5 control system as a single recipe, the machine will modify the variable parameters for each run according to the recipe-defined values and produce a specific number of tablets.

So, with very little product, several tests can be done before producing a clinical batch with a well-defined set of parameters. Plus, as clinical, pilot or commercial-scale batches can be produced on the same machine under equivalent conditions, there are no scale-up issues and often expensive and lengthy equivalence studies can be avoided. 

Batch-Based R&D

At the heart of GEA’s small-scale, batch-based R&D portfolio approach is PharmaConnect™, which allows a number of diverse process modules from GEA companies to be docked to one control unit. Based on the company’s market-leading PMA™ and Gral™ granulation technologies, and designed for laboratory through to pilot plant scale, the PharmaConnect™ can process batches from 200 g to 25 kg or more, all from a single control unit.

Continuous R&D: Direct Compression

Making its ACHEMA debut, the ConsiGma® Continuous Dosing and Blending (CDB1) system has been developed with process understanding and scale-up in mind. Designed to match the unit operations of a ConsiGma®CDC50 continuous direct compression unit, the CDB1 has been created to accelerate formulation optimization and reduce the use of high value APIs. PAT-compatible and offering flow capacities of 0.5–50 kg hour — depending on the blender size and product characteristics — the system also supports DoE work and RTD measurements. 

The data derived from the CDB1 can be used to support regulatory submissions so that customers can get products to market faster. A number of other solutions to improve the processing of small- or pilot-scale amounts of developmental products will also be on display. Plus, don't miss our future-thinking conference presentation on “Continuous Processing and Industry 4.0.”

Furthermore, on 12 June at 11:00, we’ll be holding a joint press conference with other key suppliers to the pharmaceutical sector to announce a number of industry collaborations that will help to facilitate the uptake of continuous manufacturing technology in the drug production sector.

We look forward to welcoming you to Stand F46 in Hall 4.0 and showing you how GEA is making science work.

Media Relations

GEA Group Aktiengesellschaft

Peter-Müller-Str. 12


40468

Düsseldorf


Germany

+49 211 9136-0

O GEA

GEA jest jednym z największych dostawców dla przemysłu przetwarzania żywności i wielu innych sektorów, w 2019 roku spółka wygenerowała skonsolidowane przychody na poziomie 4,9 miliarda euro.

Ta międzynarodowa grupa technologiczna specjalizuje się w produkcji maszyn, instalacji oraz technologii i komponentów procesowych. GEA dostarcza zrównoważone rozwiązania energetyczne na potrzeby skomplikowanych procesów produkcji na różnych rynkach użytkownika końcowego oraz oferuje wszechstronne portfolio usług. Około 70 procent przychodów grupy pochodzi z sektora żywności oraz napojów i alkoholi, w którym obserwowany jest długoterminowy i zrównoważony wzrost. Zgodnie ze stanem na 31 grudnia 2018 roku firma zatrudnia na całym świecie około 18 500 osób. GEA jest liderem rynkowym i technologicznym w segmentach biznesowych, w których prowadzi działalność. Spółka jest notowana na niemieckim indeksie MDAX (G1A, WKN 660 200), indeksie STOXX® Europe 600 Index oraz wybranych indeksach MSCI Global Sustainability. Więcej informacji można uzyskać w witrynie gea.com.
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