ConsiGma® Dosing and Blending (DB) Modules

Depending on its configuration and the formulation, the system can achieve throughputs of 1 to 400 kg/h. 

The Conductor 4.0 software ensures seamless control of the entire process and full reporting. Tracking of OOS and material genealogy can be integrated into the controls. Handshaking with up- or downstream equipment can also be offered. 

ConsiGma® DB modules can be implemented in a wide variety of situations, including the following:

• Dosing and blending of external phase additions (lubricant) together with a pre-blend 
• Dosing and blending of multiple (up to four components) of flowable powder materials  
• As an R&D module to investigate the dosing and blending process for NCE, orphan drugs or low-dose APIs 
• As a dosing and blending unit combined with other continuous up- or downstream processes for both low dose and high throughput products, depending on the configuration 

The modules are suitable for ethical, CDMO, generic, nutraceutical or CMO operations. 

Standard Configuration

• 2 to 4 loss-in-weight feeders 
• Linear or ribbon blender 

Available Options

• Choice of feeder (GEA or qualified third-party supplier) 
• Continuous flow or mini-batch blending capability 
• Blend uniformity measurement with Lighthouse Probe® 
• Customer selected tablet press (GEA or other – control interface to be clarified)  
• OOS rejection  
• Material genealogy 

Main Benefits

• Use with existing equipment (roller compaction, compression, etc.)  
• Continuous or mini-batch flow capability  
• Replace only a single step in the process with minimal impact as per SUPAC guidelines; plant scheduling and testing remain the same as current process. 
• Higher blend homogeneity – all powder particles go through the same mixing event  
• Higher material yield  
• High flexibility from very low to very high API content  
• In-process blend uniformity control – second-by-second  
• Compatible with variable throughput capacities