ConsiGma® Direct Compression with Ribbon Blending (DC-RB) Lines

A cost-effective solution for continuous dry blending and tablet compression using ribbon blending, ConsiGma® DC-RB lines make the advantages of continuous manufacturing (supply chain agility, small footprint and improved quality) available for all.

ConsiGma® DC-RB Lines integrate continuous dry blending using a ribbon blender and tablet compression into one efficient continuous production system.

Available in 3 standard sizes, depending on the desired throughput (from 10 to 200 kg/h or 20,000 to 400,000 tablets/h, to be verified by testing), the systems can be customized with a number of options to suit customer needs.

The Conductor 4.0 software ensures seamless control of the entire process and full reporting. Tracking of OOS and material genealogy can be integrated into the controls. 

Mainly targeted towards generics, nutraceuticals, OTC production and CMOs, the systems are designed to handle easy-to-blend and high-throughput DC formulations. 

Standard Configuration

  • 2 to 4 loss-in-weight feeders 
  • 1 ribbon blender 
  • GEA compression system

Available Options

  • Choice of feeder (GEA or qualified third-party supplier) 
  • Set-up of blender: continuous flow or mini-batch 
  • Blend uniformity measurement with Lighthouse Probe® 
  • Material handling system including containment features 

Main Benefits

  • Flexible batch size 
  • Small footprint 
  • Eliminate work in progress 
  • Adaptable to blending of even fragile particles such as MUPS   
  • Higher blend homogeneity – all powder particles go through the same mixing event  
  • Higher material yield      
  • High flexibility from very low to very high API content   
  • In-process blend uniformity control – second-by-second    
  • Adaption to variable throughput capacities  
  • No hold-up issues 

Read more about how GEA and its partners are implementing this technology to lead the way toward smaller, more flexible, continuous processing technologies that are transforming the future of pharmaceutical development and manufacturing.

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