ConsiGma®
ConsiGma® Direct Compression with Linear Blending (DC-LB) Lines
A highly integrated solution for continuous linear blending and direct compression, the ConsiGma® DC-LB lines offer all the advantages of continuous manufacturing: supply chain agility, small footprint, controlled blending and compression and improved quality.
Continuous Direct Compression
Available in 2 standard sizes, depending on the desired throughput (from 1 to 100 kg/h or 20,000 to 150,000 tablets/h to be verified by testing), the systems can be customized with a number of options to suit customer needs.
The Conductor software ensures seamless control of the entire process and provides full reporting and track & trace.
Mainly targeted towards high-value products (low dose API), orphan drugs and new chemical entities, and particularly suited for challenging recipes that require two-stage blending or more dispersive blending, the systems can be equipped with cleaning and containment features to handle highly potent formulations.
Standard Configuration
Up to 6 loss-in-weight feeders with automatic top-up systems
2 linear blenders
GEA compression system
Available Options
PAT tools
Hot swap parts for fast changeover
Material handling system including containment features
Containment upgrade
Coater
Main Benefits
Reduced risk of segregation – no material hold-ups
Highest possible blend homogeneity – all powder particles go through the same mixing event
Higher material yield
High flexibility from very low to very high API content
In process blend uniformity control – second-by-second
Adaption to variable throughput capacities
No hold-up issues
Wider drug load range than batch processing
System automatically adapts to changes in bulk density
Adaptable top-up sizes to ensure accurate feeding
Automatically adjustable dwell time
Flexible batch size
Smaller footprint
Read more about how GEA and its partners are implementing this technology to lead the way toward smaller, more flexible, continuous processing technologies that are transforming the future of pharmaceutical development and manufacturing.
Downloads
Related Products
ConsiGma® Granulation and Compression (GC) Lines
Highly integrated solutions for continuous wet granulation, drying and tablet compression, the ConsiGma® GC lines offer all the advantages of continuous manufacturing: supply chain agility, small footprint, controlled granulation and improved quality.
ConsiGma® Film Coater
The ConsiGma® Film Coater is based on the GEA high-performance tablet coating technology that gently and accurately deposits controlled amounts of coating materials onto tablet cores — even if they are hygroscopic or friable.
ConsiGma® 1 - R&D Granulation and Drying
The ConsiGma® 1 offers standalone continuous twin-screw granulation and drying for small-scale R&D operations. It allows users to develop the process and achieve high granule quality on a compact unit.
Lighthouse Probe® - online measurement
The Lighthouse Probe® can be used for real-time monitoring of chemical and pharmaceutical processes and provides in-process window cleaning at any time, recalibration during the process, full CIP (cleaning) of wash housing and seal, and a clear view inside – even in difficult conditions.
GEA Insights
Turning wastewater into value
GEA centrifuges enable wastewater reuse, resource recovery, and water security by turning biosolids into value in a world facing growing water scarcity.
Around the world in seven questions: New foods we’ll love
Last year was not a year of hyped-up headlines for alternative proteins. Perhaps that is precisely why it was an important year for food biotech, the biotechnology behind everyday foods and ingredients. While the sector worked through a difficult funding environment, approvals were still granted, pilot lines set up and new platforms tested in the background. In short: headlines are turning into infrastructure. Frederieke Reiners heads GEA’s New Food business. She and her team work at the intersection of biotechnology and industrial food production. In this interview, she takes us on a world tour of food biotech in seven questions.
How freeze-dried pet food raises the bar
Pets are family – and owners expect premium, transparent and sustainable nutrition. Freeze-drying, powered by GEA technology, helps pet food makers deliver.
