Liquid Dosage
Therapeutical Proteins
Protein-based therapeutics are increasingly being developed as new chemical entities in the pharmaceutical and life science industries. Unlike small molecules, which are typically synthesized using chemical processes, most proteins need to be processed in living systems, mostly by recombinant DNA technology. The proteins can then be produced in their functional form (quaternary structure), rather than by microbial biosynthesis (bacteria/yeast), substantially reducing the downstream stages of the process.
The GEA Advantage
As the demand for large-volume products increases, so does the requirement for higher capacity reactors (up to 20,000 L) to realize economies of scale. GEA has responded to the changing needs of biopharmaceutical manufacturers and developed improved technology solutions to optimize both upstream and, with increasing titers, downstream processing, in terms of time and cost efficiency.
Based on its history of innovation and process development, GEA has a thorough working knowledge of therapeutic protein production and has used this competence to design better media and feeding strategies, optimize the fermentation stage and enhance physicochemical conditions during the manufacturing process.
A leading international supplier of integrated process systems, our extensive portfolio of products, technologies and services includes standard and customized fermenters, separators and entire production lines, as well as plant for the production, storage and distribution of clean utilities. Systems for the preparation of media, fluid management, cell cultivation and purification are also part of our global scope of supply.
As a competent manufacturer of complete plant for the life science industries, GEA is a full-service provider of solutions that meet your exact requirements and specifications. From planning, development and installation to qualification and maintenance, our experienced engineers will collaborate with your project team to supply innovative and efficient process solutions for your applications.
Produkte und Technologien
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Absperrventile
Die aseptischen Absperrventile werden für die überwachte Öffnung und Schließung von Leitungen in UltraClean- und aseptischen Prozessanlagen eingesetzt.
Analyse-, Inline Steuer- und Messvorrichtungen
Durch die Verbindung von Prozessüberwachung per Online-Analysetools mit soliden Verfahrenstechnikprinzipien und fortschrittlichen Prozessmodellierungsmethoden können Prozesse aktiv überwacht werden, um Eingabevariationen zu kompensieren.
Aseptische Ventile & Komponenten
Aseptische Ventile erfüllen die besonders hohen Anforderungen innerhalb UltraClean- und Aseptischen Prozessen. Sie können sich darauf verlassen, dass Ihnen die höchste Qualität in Bezug auf hygienisches Design und Nachhaltigkeit angeboten wird.
Aseptisches Molchsystem
Ein aseptisches Molchsystem ermöglicht die Rückgewinnung von wertvollem Produkt aus den Produktleitungen. Dabei schiebt ein von steriler Druckluft angetriebener Molch das Produkt aus der Rohrleitung. Der an der Innenseite der Rohrleitung verbleibende Produktfilm kann dann mit der CIP entfernt werden.
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