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ConsiGma®

ConsiGma® Granulation and Compression (GC) Lines

Highly integrated solutions for continuous wet granulation, drying and tablet compression, the ConsiGma® GC lines offer all the advantages of continuous manufacturing: supply chain agility, small footprint, controlled granulation and improved quality.

Continuous Line

ConsiGma® GC Lines integrate continuous wet granulation, fluid bed drying and tablet compression into one efficient continuous production system.

Available in 3 standard sizes, depending on the desired throughput (from 5 to 120 kg/h or 20,000 to 180,000 tablets/h to be verified by testing), the systems can be customized with a number of options to suit customer needs.

The Conductor 4.0 software ensures seamless control of the entire process and provides full reporting and track & trace.

Mainly targeted towards high value products (low dose API), orphan drugs and new chemical entities, the systems can be equipped with cleaning and containment features to handle highly potent formulations.

Standard Configuration

  • 1 loss-in-weight feeder for formulation pre-mix
  • Twin-screw granulator
  • Segmented fluid bed dryer
  • Granule conditioning unit
  • GEA compression system

Available Options

  • Dosing and blending unit for preparing the formulation pre-mix
  • Melt granulation set-up
  • Solvent capable
  • PSR
  • PAT tools
  • Cleaning upgrade
  • Containment upgrade
  • Material handling system including containment features
  • TC coater modules

Main Benefits

  • Controlled granulation
    • Better distribution of granulation binder
    • Porosity control of the granules  
    • Control of granule particle size distribution
  • Small amount of product in process (minimal amount of API at risk of OOS)
  • Elimination of work-in-progress
  • Increased flexibility from very low to very high API content 
  • Use of solvent-free binders
  • Compatible with variable throughput capacities
  • Flexible batch size
  • Smaller footprint

Produtos relacionados

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Process optimisation depends on efficient, effective cleaning. Clean-in-Place (CIP) systems can be incorporated into all the equipment produced by GEA for the pharmaceutical industry, including fluid bed dryers, high-shear granulators and liquid dosage formulation systems. Automating the cleaning process ensures repeatability, allows validation and minimizes downtime.

ConsiGma® Compact Feeder (CF) Test Rig

ConsiGma® Compact Feeder (CF) Test Rig

The ConsiGma® CF20 test rig is a standalone module that allows you to characterize the feeding behavior of your products during the early stages of R&D.

ConsiGma® Conductor 4.0

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ConsiGma® Direct Compression with Linear Blending (DC-LB) Lines

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ConsiGma® Direct Compression with Ribbon Blending (DC-RB) Lines

ConsiGma® Direct Compression with Ribbon Blending (DC-RB) Lines

A cost-effective solution for continuous dry blending and tablet compression using ribbon blending, ConsiGma® DC-RB lines make the advantages of continuous manufacturing (supply chain agility, small footprint and improved quality) available for all.

ConsiGma® Dosing and Blending (DB) Modules

ConsiGma® Dosing and Blending (DB) Modules

Designed to achieve optimal blending results, the ConsiGma® DB modules facilitate the testing of dosing and blending operations and can be integrated with any continuous up- or downstream process.

ConsiGma® Granulation and Drying (GD) Modules

ConsiGma® Granulation and Drying (GD) Modules

Based on proven continuous twin-screw granulation technology, the ConsiGma® GD modules enable the production of higher quality granules under better control, even in a bin-2-bin set-up.

ConsiGma® PAT Test Rig

ConsiGma® PAT Test Rig

This standalone module allows you to start developing your PAT models for the continuous manufacturing process offline during the early stages of R&D.

ConsiGma® Tablet Coating (TC) Modules

ConsiGma® Tablet Coating (TC) Modules

After compression, many tablet formulations need a coating to achieve the final product characteristics desired. To complete the ConsiGma™ tableting lines, GEA has developed a coater in line with its continuous manufacturing concept.

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Lighthouse Probe™ - online measurement

The Lighthouse Probe™ can be used for real-time monitoring of chemical and pharmaceutical processes and provides in-process window cleaning at any time, recalibration during the process, full CIP (cleaning) of wash housing and seal, and a clear view inside – even in difficult conditions.

MODUL™ Tablet Press Technology

MODUL™ Tablet Press Technology

All MODUL™ tablet presses are based on the Courtoy™ Exchangeable Compression Module (ECM) concept. The ECM is completely isolated from the remainder of the machine, contains all product contact parts and can easily be removed from the press in a contained way. This means that the press itself remains powder-free and requires no cleaning.

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No início do desenvolvimento da pesquisa e formulação, a disponibilidade do ingrediente ativo é frequentemente muito limitada e existe uma necessidade de um equipamento de processo que seja capaz de produzir somente algumas centenas de gramas para desenvolver novas fórmulas de medicamentos. Em resposta a essa necessidade, a GEA desenvolveu o ConsiGma™ 1, a versão de escala de laboratorial do conceito ConsiGma™.

Wash-Off-Line for Pharmaceutical Plants

Wash-Off-Line for Pharmaceutical Plants

In addition to providing complete containment services, GEA also offers multifunctional wash skids that can be moved from one location to another and used to clean different parts of the process. Every plant delivered by GEA has a tailor made CIP, WIP or Wash-Off-Line (WOL) system to suit your application.

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