CPhI 2017

In early research and formulation development, the availability of the active ingredient is often very limited and there is a need for process equipment that is capable of producing only a couple of hundred grams to develop new drug formulas. In response to this need, GEA developed ConsiGma™ 1, the lab-scale version of the ConsiGma™ concept.

The IPS25 combines the NICA™ Extruder with Spheronizer to deliver a market-leading solution for pilot-scale pellet production. Fitted with an actuated dosing valve, the system can automatically transfer consistent batches from the extruder to spheronizer and deliver a continuous production capacity of around 25 kg/h. Operating in manual mode, the IPS25 is equally suitable for lab-scale operations with batch sizes as little as 400 g.

• The GEA MODUL™ Q features GEA’s Exchangeable Compression Module (ECM), which offers higher levels of containment performance. 
• The press also incorporates an Exchangeable Die Disc. 
• With a bigger pitch diameter and the use of A-type tooling, the MODUL™ Q can accommodate 51 punch stations and produce more than 367,200 tablets per hour. 
• Single and bilayer tableting, 
• Adjustable dwell time control at pre and main compression and OEE monitoring
• New MULTI-CONTROL 5 control system

Providing the highest levels of containment and built on the successful BUCK® MC Valve platform, the BUCK® UMC Valve utilizes a vacuum extraction system to provide containment levels down to 0.1 – 1.0 mcg/m³ based on STTWA. The UMC Valve offers a modular containment solution that can be equipped to fit most secondary pharma applications.

Fundamentally different to all other containment valves, the MC Valve moves away from the old passive and active set-up now utilising identical half valves on both container and process equipment to provide containment in the range 1.0-10.0 mcg/m³ STTWA. This step change in split butterfly valve design is supported with the MC Lite Actuator ring. The MC Lite Actuator Ring weighing less than 4kg can be moved around a facility and used to manually dock, lock and open any two BUCK® MC Half Valves improving operational flexibility while reducing initial equipment outlay and ongoing equipment maintenance costs.

Offering an improved design but maintaining the same compact footprint, the MM-100 spray dryer from GEA, equipped with the new and highly efficient cyclone CEE (Cyclone Extra Efficiency), is the newest addition to the MOBILE MINOR™ 

The newly developed cyclone CEE offers a higher separation efficiency, which increases the yield and reduces emission. In real life tests, the CEE powder separation efficiency was verified as being considerably higher than the efficiency of standard cyclones. All comparisons were made with the same pressure loss over the units. The efficiency was tested for a range of particle sizes, air flows and powder loadings and superior performance was verified for all combinations.

Installed in almost 2400 plants worldwide, the cross-application MOBILE MINOR™ spray dryer is robust, reliable and versatile. It is easy to use, clean and move and an ideal basis for up-scaling a new process.

Further special features of the MOBIE MINOR™:

• Process gas flow up to 100 kg/h at 200 °C for increased capacity
• Accurate gas disperser for minimizing powder deposits
• High capacity HEPA filters for baby food or hazardous chemical applications available
• Powder collection glasses in sizes from 250–3500 mL can be supplied as standard.
• The universal gas disperser for the rotary atomizer as well as the two-fluid nozzle can easily be exchanged with an optional low velocity gas disperser — which has a similar flow pattern to the DPH gas dispersers used in larger PHARMASD™ spray dryers — for nozzle atomization.
• Powerful supply blower with flow indication
• Easy to remove and clean laser-cut gas guides (patent pending).

The PandaPLUS 2000 is a small table-top laboratory unit, designed for continuous operation at high pressure - the perfect equipment for the processing of nanoparticles, nanodispersions, nanoemulsions and cell disruption.

• Full scalability of results
• Optimizing the use of pressure
• Verifing the homogenization effects on the final product and fining tune the perfect product formulation
• High reliability of performance over time
• Limited maintenance
• Improved performance thanks to Re+VALVE in ceramic or tungsten carbide

The GEA separator skid in the sophisticated compact format for pharmaceutical applications requires little space in the technical centre and, thanks to its sensible design, reliably fulfils even the most demanding technical tasks. You can easily scale the results to any desired production size with no problem. As such, the full functionality of large pharmaceutical centrifuges is available to you in the simplest way, allowing you to concentrate fully on the creative development of your products.

The GEA pathfinder GMP is exceptionally easy to operate. The complete preparation, use and maintenance make the smallest possible demands on your team. The system arrives in the technical centre ready for instant use, pre-installed with all connections and control modules in one compact unit that fi ts even through a 900-mm door.

The plant is the first of its type to be equipped with a package of GMP basic certificates for optimal fulfilment of hygiene requirements. From there on, there is nothing standing in the way of your next product success.

GEA pathfinder GMP at a glance

• Complete functionality of large pharmaceutical centrifuges
• Cost-effective, compact, time-saving, straightforward
• Production results that can be scaled with no problem
• Inclusive package of GMP basic certificates
• 20,000 g for reliably separation of the finest particles even with slight density differences
• Three bowl sizes at a flow rate of 15 l/h – 300 l/h.