Интегрированные линии гранулирования

Current good manufacturing practices increasingly require that product is fully contained during processing to protect both operators and the environment. Integrated process systems not only offer containment, but also provide improved productivity through automation, increased yield and efficient cleaning procedures. And, today’s increased demands for customized design, special construction materials, surface treatments, advanced control systems, compliant production and process validation have resulted in continuous improvements in solid dosage plant design for the pharmaceutical and nutraceutical industries.

Integration by Design

GEA is uniquely qualified to provide integrated pharmaceutical process lines. Drawing on its world-class expertise and technologies, we offer an entire range of state-of-the-art process equipment that has been designed and built with system integration in mind. 

A modular approach allows customers to select standard process modules to suit specific project needs: fully integrated turnkey installations can be supplied, including fluid bed process equipment combined with top- and bottom-drive high shear mixer-granulators with integrated contained materials handling, wet and dry milling facilities, product handling systems, binder and coating preparation units, filtration units and tablet compression machines.

Safe and Contained

Safety, containment, product flow and building requirements are in-built for full integration and optimum process efficiency. Our service includes design, installation assistance, commissioning and process validation, as well as training and technical support. Installation, operation qualification and documentation are done according to FDA/GAMP guidelines.

Safety, containment, product flow and building requirements are in-built for full integration and optimum process efficiency. Our service includes design, installation assistance, commissioning and process validation, as well as training and technical support. Installation, operation qualification and documentation are done according to FDA/GAMP guidelines.

End-Point Detection

The US FDA’s PAT (Process Analytical Technology) initiative has enabled GEA to combine its equipment design skills and process engineering know-how to integrate online (PAT) analyzers into its systems in a way that can provides real insight into the operation of the process and help customers to achieve key product quality targets. 

The goal of the PAT initiative is to ensure that pharmaceutical products are manufactured using processes that are understood and monitored so that the key quality characteristics of the products can be actively controlled.