P-MEC India 2017

In early research and formulation development, the availability of the active ingredient is often very limited and there is a need for process equipment that is capable of producing only a couple of hundred grams to develop new drug formulas. In response to this need, GEA developed ConsiGma™ 1, the lab-scale version of the ConsiGma™ concept.

To increase process yield and guarantee tablet quality, an innovative new MUPS production method — a continuous dosing, blending and compression system — has been developed that eliminates these production inefficiencies and product quality risks. Segregation is kept to an absolute minimum and online process monitoring detects OOS tablets. 

Capacity: 400 liters 

GEA’s high productivity Integrated Granulation Line technology demonstrate bin to bin concept consisting of Pharma Matrix (PMA) with Integrated wet mill with auto discharge into fluid bed processor in a closed system. The fluid bed processor is integrated with latest “Lean Phase Transfer System” which enhance the discharging rate of dried granules into the bin via an integrated dry mill. The integrated granulation system by GEA provides key benefits to customers from pharma industry:

• High productivity
• Through-the-wall GMP design 
• Smaller footprint, effective utilization of GMP area.
• Close transfer avoids cross-contamination
• 10 bar PSR design lowers structural requirement

GEA has notable installations in India for application production of: Metforming, Metaprolol, Amoxyline, Listenopril etc.

Containment issues are becoming an increasingly important aspect of solid dosage form production, especially for highly potent and toxic active pharmaceutical ingredients (APIs) for hormone and oncology applications. With a more intense focus on health and safety, avoiding both operator exposure and preventing cross-contamination is critical.

With thousands of global implementations and more than 20 years of experience, GEA has pioneered pharmaceutical containment. We can assist and advise you to determine what level of containment is required where and when, optimizing the manufacturing process and making it efficient, safe and cost-effective. We provide tailor-made containment for the pharmaceutical industry — for now and for the future.” 

From equipment design, smart hardware, compression, contamination-free sampling, integrated cleaning, process intelligence and beyond, GEA not only offers a comprehensive range of robust and compliant containment products, it also boasts unrivalled experience in identifying the most appropriate solution and a thorough understanding of containment risk analysis.

Safe, efficient and cost-effective, GEA manufactures a completely integrated range of materials handling equipment for the pharmaceutical and life science industries. 

Taking an individual approach to each customer’s needs — from powder to coated tablet — and applying our extensive experience and know-how, we combine performance excellence with technological innovation to deliver long-term competitive advantages. Committed to quality and GMP standards, we work together with our customers to deliver first-class tailored solutions for projects of all sizes and complexity.

And, with thousands of installations worldwide, GEA has developed an outstanding reputation for quality and service to become the clear leader in contained materials handling technology, including powder handling, intermediate bulk container (IBC) systems, containment valves, container systems, in-container blending, tablet handling and IBC washing.

The process lines provided by GEA have a proven track record in API production, including fermentation, clarification, membrane filtration and separation, homogenization and micronization, crystallization, concentration, lyophilization and fractionation. 

As well as complete integration with upstream and downstream processes, our standalone machines or package units guarantee a high yield of valuable substances and operate trouble-free, efficiently, reliably and economically throughout a long service life.

Offering a comprehensive range of services and project management, we guarantee successful outcomes and a tailor-made solution for your application. 

Suket Gohil, Head Solutions Sales, India Cluster, notes: “P-MEC India is always a great show for us and, perhaps, our best to date. With 1200 companies exhibiting at the event and, considering the ageing population, increased urbanisation, better access to healthcare and a higher incidence of chronic diseases, especially diabetes and cardiovascular disease, we’re expecting to see significant growth during the next few years.”

Navin Lakhanpaul, Vice President Asia Pacific, APC Pharma, adds: “The country’s increased focus on regulatory compliance and industry standardisation, as well as its export acumen and synergy with the US, is key to the future success of the Indian pharmaceutical industry.”

The GEA separator skid in the sophisticated compact format for pharmaceutical applications requires little space in the technical centre and, thanks to its sensible design, reliably fulfils even the most demanding technical tasks. You can easily scale the results to any desired production size with no problem. As such, the full functionality of large pharmaceutical centrifuges is available to you in the simplest way, allowing you to concentrate fully on the creative development of your products.

The GEA pathfinder GMP is exceptionally easy to operate. The complete preparation, use and maintenance make the smallest possible demands on your team. The system arrives in the technical centre ready for instant use, pre-installed with all connections and control modules in one compact unit that fi ts even through a 900-mm door.

The plant is the first of its type to be equipped with a package of GMP basic certificates for optimal fulfilment of hygiene requirements. From there on, there is nothing standing in the way of your next product success.

GEA pathfinder GMP at a glance

• Complete functionality of large pharmaceutical centrifuges
• Cost-effective, compact, time-saving, straightforward
• Production results that can be scaled with no problem
• Inclusive package of GMP basic certificates
• 20,000 g for reliably separation of the finest particles even with slight density differences
• Three bowl sizes at a flow rate of 15 l/h – 300 l/h.