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ConsiGma®

ConsiGma® Direct Compression with Linear Blending (DC-LB) Lines

A highly integrated solution for continuous linear blending and direct compression, the ConsiGma® DC-LB lines offer all the advantages of continuous manufacturing: supply chain agility, small footprint, controlled blending and compression and improved quality.

Pharma Technology Compression

ConsiGma® DC-LB Lines integrate continuous dry blending using linear blenders and tablet compression into one efficient continuous production system.

Available in 2 standard sizes, depending on the desired throughput (from 1 to 100 kg/h or 20,000 to 150,000 tablets/h to be verified by testing), the systems can be customized with a number of options to suit customer needs.

The Conductor 4.0 software ensures seamless control of the entire process and provides full reporting and track & trace.

Mainly targeted towards high-value products (low dose API), orphan drugs and new chemical entities, and particularly suited for challenging recipes that require two-stage blending or more dispersive blending, the systems can be equipped with cleaning and containment features to handle highly potent formulations.

Standard Configuration

  • Up to 6 loss-in-weight feeders with automatic top-up systems

  • 2 linear blenders

  • GEA compression system

Available Options

  • PAT tools

  • Hot swap parts for fast changeover

  • Material handling system including containment features

  • Containment upgrade

  • Coater

Main Benefits

  • Reduced risk of segregation – no material hold-ups

  • Highest possible blend homogeneity – all powder particles go through the same mixing event

  • Higher material yield

  • High flexibility from very low to very high API content

  • In process blend uniformity control – second-by-second

  • Adaption to variable throughput capacities

  • No hold-up issues

  • Wider drug load range than batch processing

  • System automatically adapts to changes in bulk density

  • Adaptable top-up sizes to ensure accurate feeding

  • Automatically adjustable dwell time

  • Flexible batch size

  • Smaller footprint

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