Spray Drying for Pharma Applications

ASEPTIC-SD® spray dryer

For decades, spray drying has been applied for powder production by the pharmaceutical industry – also under aseptic conditions. The ASEPTIC-SD® Spray Dryer is perfect for the production of sterile pharmaceutical products such as vaccines, antibiotics and other products requiring aseptic conditions.

GEA Niro ASEPTIC Flowsheet 2
Designed specifically for aseptic processing, combining proven GEA technology and know-how within sterilisation, the ASEPTIC-SD® Spray Dryers allow you the advantage of exploiting all the benefits of spray drying while still meeting the strictest requirements to aseptic processing.

Aseptic Spray Drying

Aseptic Spray Drying

A precise control of the drying process gives far greater command over the shape, density and morphology of the final product than other aseptic drying technology, and moreover, with low running and capital costs, these advantages are obtained while reducing overheads.

Production of dry sterile dosage forms often involves mixing of the API with one or more excipients. To achieve a homogeneous mixture, the particle size distribution of the excipient(s) must match that of the API. In a one-step-operation, aseptic spray drying can turn a sterile solution into sterile particles of the required size with no risk of introducing impurities.

The spray dryers are also designed for handling organic solvents, which makes possible the use of a wide range of excipients within the formulation.

Sterilization by Clean Steam

Sterilization using pure steam is the preferred and proven method within the pharmaceutical industry. For complex designs and where the product is in contact with the equipment surface, air pockets must be removed by applying vacuum. These challenging requirements are met by the new generation of GEA ASEPTIC-SD® Spray Dryers (patents pending).

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