Dry Bonding (Dry Mixing)
Whatever the subsequent production steps, the formulation of an active compound and other excipients needs to be mixed homogeneously. Low shear mixing relies on the planetary movement of the mixer arm to achieve homogeneity, whereas high shear mixing uses a high intensity mixing blade to produce a homogenous blend. Which technique is most suitable depends on the subsequent production step. GEA can help you to make the right choice.
High Speed Blending for DPI's
In additional to conventional wet granulation processes, GEA also provides a key technology for the inhalation industry. The TRV (Turbo Rapid Variable) is a high speed blending unit that features a single, bottom driven impeller drive. It is particularly suitable for the rapid batch blending of small quantities of pharmaceutical active ingredients with base excipients, typical of inhalable products.
By combining the high surface area of the main impeller blade with the directional effects of the feeder blade, rapid, homogenous and stable blends can be produced in a reproducible manner. The TRV can be paired with our modular PharmaConnect™ system to allow a number of diverse processes to be connected to a single control system. In the case of the TRV, we are able to supply a single control panel that can operate 1, 5, 10, 20, 30 and 60 L TRV process modules.