Ointments & Creams
GEA supplies comprehensive system engineering and project management for the production of creams and ointments in the pharmaceutical, biotechnology and personal care industries.
Integrated Production Solutions
Mixing is the most demanding unit operation in today’s process industries — and a high-quality end product is dependent on efficient and successful mixing. One of our core applications is mixing solutions for liquid/liquid or liquid/powder, and we are proud to say that we have many years of experience in this field. Choosing the right mixing technology is crucial — as the mixing process not only has an impact on the processing — but also on the batch cycle times and the total cost of ownership. One of the success criteria related to mixing processes is ending up with a homogenous final product without ‘fish eyes’ and lumps of powder — in the shortest possible time. Our technology will make you rethink the traditional way of mixing.
Process integration: we integrate equipment, systems and components into your operating process plant. We can design and deliver equipment for powder mixing, liquid mixing and blending, fermentation lines, ferment separation, GMO kill plants, intermediate storage, temperature treatment (pasteurization/UHT) and membrane filtration, separators, dryers or freeze dryers.
Cleaning technology: for Cleaning-in-Place (CIP) and Sterilisation-in-Place (SIP), we are able to offer the optimal system for every task, from stationary spray balls and rotating jet cleaners to universally used modular SRS standard cleaning systems. We have developed single use, recovery, CIP systems and automatic washing cabin systems to clean and dry mobile bulk containers. The product recovery system has been developed to reduce valuable product loss by integrating this with the process.
Process automation to monitor and control all process steps, including information and management systems developed in accordance with the customer's detailed requirements.
Hygienic and sterile process plants that can be validated according to MCA, FDA and other regulatory standards, as part of the project validation master plan, which includes the following:
- Design Qualification (DQ)
- Installation Qualification (IQ)
- Operational Qualification (OQ)
- In addition, we can participate in PQ.
Micronization using high pressure homogenization is used to obtain a homogenous and stable product emulsion, with better active ingredient dispersion than can be achieved with conventional stirrers, rotor-stator devices or colloid mills. High pressure homogenization can effectively reduce the particle size down to nanometer scale with uniform dimensional distribution, forcing the product through a special homogenizing valve using high pressure energy through fluid-dynamic effects like shear, turbulence, cavitation, acceleration and impact.
The stabilization of emulsions containing different oils is often required for semi-solid applications, and droplet micronization and efficient dispersion eliminate water phase separation, improve both active ingredient and excipient distribution. Effective particle size reduction with high-pressure homogenization is used to obtain a better quality product that can be easily and more effectively absorbed by the skin.